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This Concept Map, created with IHMC CmapTools, has information related to: Xeroderma Pigmentosum, Xeroderma pigmentosum results in High mutation rate due to UV radiation, Endonucleases which Cleave DNA at the dimer site, High mutation rate due to UV radiation leads to Frequent skin tumors, High mutation rate due to UV radiation leads to Photosensitivity, Nucleotide excision repair system encoded by 28 different genes, High mutation rate due to UV radiation leads to abnormal skin pigmentation, High mutation rate due to UV radiation leads to Extensive freckling, Pyrimidine dimers caused by UV radiation, Xeroderma pigmentosum which means "Dry Pigmented Skin", High mutation rate due to UV radiation leads to Cataracts, 28 different genes can have Mutations, UV radiation result in Missense mutations, Nucleotide excision repair system removes Pyrimidine dimers, Mutations as in Xeroderma pigmentosum, Pyrimidine dimers by Endonucleases, Frequent skin tumors as in Two hit model